At the forefront of PDGF research
Dr. Lynch is the world’s leading authority on growth factors, specifically PDGF research and commercialization. He has over 120 patents and over 150 published papers. Additionally, there is a body of work spanning over 1,000 published articles evaluating PDGF.
Explore the decades-long body of research to discover Dr. Lynch’s unmatched contribution to the advancement, innovation, and proliferation of PDGF in medicine and cosmetics.
PDGF studies
Mechanism of action
- Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications (Hollinger, et al, 2008) - PMID: 18292357
- Comparative study of various growth factors and cytokines on type I collagen and hyaluronan production in human dermal fibroblasts (Kim, MS, et al, 2014) - PMID: 24641605
- Dermal fibroblasts have different extracellular matrix profiles induced by TGF‑β, PDGF and IL‑6 in a model for skin fibrosis (Juhl, et al, 2020) - PMID: 33057073
- Comprehensive Analysis of Chemotactic Factors for Bone Marrow Mesenchymal Stem Cells (Ozaki, et al, 2007) - PMID: 17348810
- Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts (Antoniades et al, 1991) - PMID: 1846446
- Safety of recombinant human platelet-derived growth factor-BB in Augment® Bone Graft (Solchaga et al, 2012) - PMID: 22511993
- Preclinical Toxicology Studies of Recombinant Human Platelet-Derived Growth Factor-BB Either Alone or in Combination with Beta-Tricalcium Phosphate and Type I Collagen (Young et al., 2010) - PMID: 21350649
Augment & Augment Injectable studies
Phase III pivotal clinical trials & additional clinical trials
- Recombinant Human Platelet-Derived Growth Factor-BB and Beta-Tricalcium Phosphate (rhPDGF-BB/b-TCP): An Alternative to Autogenous Bone Graft (DiGiovanni et al, 2013) - PMID: 23824386
- The Impact of Patient Age on Foot and Ankle Arthrodesis Supplemented with Autograft or an Autograft Alternative (rhPDGF-BB/b-TCP) (Bertlet, et al, 2020) - PMID: 33376929
- A Multicenter, Retrospective, Case Series of Patients with Charcot Neuroarthropathy Deformities Undergoing Arthrodesis Utilizing Recombinant Human Platelet-derived Growth Factor with Beta-Tricalcium Phosphate (Loveland, et al, 2021) - PMID: 33158722
- A retrospective review of recombinant human platelet-derived growth factor with beta-tricalcium phosphate bone graft substitute use in hindfoot and/or ankle arthrodesis (Loveland et al, 2023) - PMID: 37727282
GEM 21S studies
Phase III pivotal clinical trials & additional clinical trials
- Platelet-Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain: Results of a Large Multicenter Randomized Controlled Trial (Nevins et al, 2005) - PMID: 16332231
- Histologic Evidence of Oral and Periodontal Regeneration Using Recombinant Human Platelet-Derived Growth Factor (Meghil et al, 2023) - PMID: 37109634
- Recombinant Human Platelet–Derived Growth Factor: A Systematic Review of Clinical Findings in Oral Regenerative Procedures (Tavelli et al, 2022) - PMID: 32392438
- Periodontal Regeneration in Humans Using Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB) and Allogenic Bone (Nevins et al, 2003) - PMID: 14584860
Regranex studies
Phase III pivotal clinical trials & additional clinical trials
- Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies (Smiell et al, 1999) - PMID: 10564562
- Becaplermin gel in the treatment of pressure ulcers: a phase II randomized, double-blind, placebo-controlled study (Rees et al, 1999) - PMID: 10417749
- Clinical Efficacy of Becaplermin (rhPDGF-BB) Gel (Wiemann et al, 1998) - PMID: 9777976
- Efficacy and Safely of a Topical Gel Formulation of Recombinant Human Platelet-Derived Growth Factor-BB (Becaplermin) in Patients With Chronic Neuropathic Diabetic Ulcers (Wiemann, et al, 1998) - PMID: 9589248
- Efficacy of topical recombinant human platelet-derived growth factor for treatment of diabetic lower-extremity ulcers: Systematic review and meta-analysis (Zhao et al, 2014) - PMID: 25060693
- A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers (Fang et al., 2008) - PMID: 19707423